WS1: Alternative Splicing
Alternative splicing (AS) generates multiple transcripts and protein products from a single eukaryotic gene. Genome-wide analyses have
established the prevalence of alternative splicing in higher eukaryotes. Alternative splicing provides a major mechanism for regulation
of gene function and has been implicated in a number of human diseases.
The study of alternative splicing has benefited tremendously from computational analyses of genomic data. The purpose of this CSB
workshop is to cover latest results and challenges in genomic and bioinformatic analyses of alternative splicing. We hope to bring
computational biologists and experimentalists together to this exciting field. This one-day workshop will consist of 8 talks
(approximately 30 minutes each).
Speakers:
• Bafna, Vineet Ph.D.
Department of Computer Science, University of California, San Diego (UCSD)
"Proteogenomic annotation"
• Clark, Tyson, Ph.D.
Affymetrix
"Discovery of tissue-specific exons using comprehensive human exon microarrays"
• Fu, Xiang-dong, Ph.D.
Department of Cellular & Molecular Medicine, University of California, San Diego (UCSD)
"Co-transcriptional regulation of alternative splicing in mammalian cells"
• Lee, Christopher, Ph.D.
Department of Biochemistry & Molecular Biology Institute, University of California, Los Angeles (UCLA)
"Alternative splicing and the evolution of exon duplications in insect DSCAM genes"
• Lee, Ji-Ann
Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles (UCLA)
"Genome-wide identification of splicing changes in response to neuronal depolarization"
• Xing, Yi, Ph.D.
Department of Internal Medicine, Carver College of Medicine & Department of Biomedical Engineering, University of Iowa
"Exon array analysis of gene expression"
• Xu, Ying, Ph.D.
Department of Biochemistry and Molecular Biology/Institute of Bioinformatics, University of Georgia
"Structural studies of alternatively spliced protein isoforms"
• Yeo, Gene, Ph.D.
Crick-Jacobs Center for Computational and Theoretical Biology, Salk Institute
"Discovery of intronic splicing regulatory elements"
Organizers:
Jun-tao Guo, University of Georgia, GA, USA
Yi Xing, University of Iowa, IA, USA